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Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis Formula

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Inhibitor Concentration given IEC is defined as the number of moles of inhibitor present per liter of solution of the system. Check FAQs

I IEC = ((\frac{(\frac{k 2 \cdot [E 0] \cdot S}{V 0}) - S}{K M}) - 1) \cdot K i

I_IEC - Inhibitor Concentration given IEC?k₂ - Final Rate Constant?[E₀] - Initial Enzyme Concentration?S - Substrate Concentration?V₀ - Initial Reaction Rate?K_M - Michaelis Constant?K_i - Enzyme Inhibitor Dissociation Constant?

Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis Example

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Here is how the Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis equation looks like with Values.

Here is how the Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis equation looks like with Units.

Here is how the Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis equation looks like.

48527.0556 = ((\frac{(\frac{23 \cdot 100 \cdot 1.5}{0.45}) - 1.5}{3}) - 1) \cdot 19

48527.0556mol/L = ((\frac{(\frac{23s⁻¹ \cdot 100mol/L \cdot 1.5mol/L}{0.45mol/L*s}) - 1.5mol/L}{3mol/L}) - 1) \cdot 19mol/L

48527.0556 = ((\frac{(\frac{23 \cdot 100 \cdot 1.5}{0.45}) - 1.5}{3}) - 1) \cdot 19

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Home » Chemistry » Chemical Kinetics » Enzyme Kinetics » Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis

Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis Solution

Follow our step by step solution on how to calculate Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis?

FIRST Step Consider the formula

I IEC = ((\frac{(\frac{k 2 \cdot [E 0] \cdot S}{V 0}) - S}{K M}) - 1) \cdot K i

Next Step Substitute values of Variables

∴

I IEC = ((\frac{(\frac{23s⁻¹ \cdot 100mol/L \cdot 1.5mol/L}{0.45mol/L*s}) - 1.5mol/L}{3mol/L}) - 1) \cdot 19mol/L

Next Step Convert Units

∴

I IEC = ((\frac{(\frac{23s⁻¹ \cdot 100000mol/m³ \cdot 1500mol/m³}{450mol/m³*s}) - 1500mol/m³}{3000mol/m³}) - 1) \cdot 19000mol/m³

Next Step Prepare to Evaluate

∴

I IEC = ((\frac{(\frac{23 \cdot 100000 \cdot 1500}{450}) - 1500}{3000}) - 1) \cdot 19000

Next Step Evaluate

∴

I IEC = 48527055.5555556mol/m³

Next Step Convert to Output's Unit

∴

I IEC = 48527.0555555556mol/L

LAST Step Rounding Answer

∴

I IEC = 48527.0556mol/L

Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis Formula Elements

Variables

Inhibitor Concentration given IEC

Inhibitor Concentration given IEC is defined as the number of moles of inhibitor present per liter of solution of the system.

Symbol: I_IEC

Measurement: Molar ConcentrationUnit: mol/L

Note: Value can be positive or negative.

Final Rate Constant

The Final Rate Constant is the rate constant when the enzyme-substrate complex on reaction with inhibitor is converted into the enzyme catalyst and product.

Symbol: k₂

Measurement: First Order Reaction Rate ConstantUnit: s⁻¹

Note: Value can be positive or negative.

Initial Enzyme Concentration

The Initial Enzyme Concentration is defined as the concentration of enzyme at the start of the reaction.

Symbol: [E₀]

Measurement: Molar ConcentrationUnit: mol/L

Note: Value should be greater than 0.

Substrate Concentration

The Substrate Concentration is the number of moles of substrate per liter solution.

Symbol: S

Measurement: Molar ConcentrationUnit: mol/L

Note: Value can be positive or negative.

Initial Reaction Rate

The Initial Reaction Rate is defined as the initial speed at which a chemical reaction takes place.

Symbol: V₀

Measurement: Reaction RateUnit: mol/L*s

Note: Value can be positive or negative.

Michaelis Constant

The Michaelis Constant is numerically equal to the substrate concentration at which the reaction rate is half of the maximum rate of the system.

Symbol: K_M

Measurement: Molar ConcentrationUnit: mol/L

Note: Value can be positive or negative.

Enzyme Inhibitor Dissociation Constant

The Enzyme Inhibitor Dissociation Constant is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured.

Symbol: K_i

Measurement: Molar ConcentrationUnit: mol/L

Note: Value can be positive or negative.

Credits

Created by Prashant Singh

K J Somaiya College of science (K J Somaiya), Mumbai

Prashant Singh has created this Formula and 700+ more formulas!

Verified by Prerana Bakli

University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA

Prerana Bakli has verified this Formula and 1600+ more formulas!

Other formulas in Competitive Inhibitor category

Go Modifying Factor of Enzyme Substrate Complex

α' = 1 + (\frac{I}{K i'})

Go Initial Rate of System given Rate Constant and Enzyme Substrate Complex Concentration

V RC = k 2 \cdot ES

How to Evaluate Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis?

Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis evaluator uses Inhibitor Concentration given IEC = (((((Final Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/Michaelis Constant)-1)*Enzyme Inhibitor Dissociation Constant to evaluate the Inhibitor Concentration given IEC, The Inhibitor concentration for competitive inhibition of enzyme catalysis formula is defined as a plot of the reaction velocity (V0) associated with the concentration [S] of the substrate which can then be used to determine values such as Vmax, initial velocity, and Km. Inhibitor Concentration given IEC is denoted by I_IEC symbol.

How to evaluate Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis using this online evaluator? To use this online evaluator for Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis, enter Final Rate Constant (k₂), Initial Enzyme Concentration ([E₀]), Substrate Concentration (S), Initial Reaction Rate (V₀), Michaelis Constant (K_M) & Enzyme Inhibitor Dissociation Constant (K_i) and hit the calculate button.

FAQs on Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis

What is the formula to find Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis?

The formula of Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis is expressed as Inhibitor Concentration given IEC = (((((Final Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/Michaelis Constant)-1)*Enzyme Inhibitor Dissociation Constant. Here is an example- 48.52706 = (((((23*100000*1500)/450)-1500)/3000)-1)*19000.

How to calculate Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis?

With Final Rate Constant (k₂), Initial Enzyme Concentration ([E₀]), Substrate Concentration (S), Initial Reaction Rate (V₀), Michaelis Constant (K_M) & Enzyme Inhibitor Dissociation Constant (K_i) we can find Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis using the formula - Inhibitor Concentration given IEC = (((((Final Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/Initial Reaction Rate)-Substrate Concentration)/Michaelis Constant)-1)*Enzyme Inhibitor Dissociation Constant.

Can the Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis be negative?

Yes, the Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis, measured in Molar Concentration can be negative.

Which unit is used to measure Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis?

Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis is usually measured using the Mole per Liter[mol/L] for Molar Concentration. Mole per Cubic Meter[mol/L], Mole per Cubic Millimeter[mol/L], Kilomole per Cubic Meter[mol/L] are the few other units in which Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis can be measured.

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Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis Formula

Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis Example

Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis Solution

Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis Formula Elements

Credits

Other formulas in Competitive Inhibitor category

How to Evaluate Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis?

FAQs on Inhibitor Concentration for Competitive Inhibition of Enzyme Catalysis

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